13 Facts About Skin

Skin isn't just the outermost layer of our bodies. Without it, we couldn't do most of the things we take for granted, like breathing, moving, and keeping the body's inner workings where they belong. And while skin also evolved to keep pathogens and other bad stuff out of our bodies, consumers spend millions of dollars on products to penetrate that defense (with mixed results). Read on for more fascinating facts about the skin.

1. YOUR SKIN HAS THREE DISTINCT LAYERS.

Skin is considered an organ in its own right. It's comprised of three layers: the waterproof top layer, the epidermis; a middle layer of tougher connective tissue, hair follicles, and glands called the dermis; and the inner layer, the hypodermis, which is mostly fat and connective tissue that supports the skin's structure and attaches it to muscles.

2. SKIN COLOR IS DETERMINED BY CELLS IN THE EPIDERMIS.

Those cells are known as melanocytes, which secrete a pigmented substance called melanin; the more melanin in the cells, the darker the skin. Having too little or too much melanin can lead to some skin color disorders: On one end of the spectrum are conditions like vitiligo—which occurs when some melanocytes lose the ability to produce melanin, resulting in whitish patches on the skin—and albinism, a condition in which melanocytes don't produce any melanin. On the other end is hyperpigmentation—the presence of excess melanin, which can cause darker patches of skin.

3. YOUR SKIN COULD WEIGH MORE THAN 20 POUNDS.

"Your skin accounts for 15 percent of your body weight," says Toral Patel, M.D., a board-certified dermatologist and supervising physician at D&A Dermatology in Chicago and a clinical instructor of medicine at Northwestern University. This makes it your body's largest organ.

According to that calculation and data from the Centers for Disease Control and Prevention, an average American woman weighs 168.5 pounds and carries more than 25 pounds of skin. An average man weighing 195.7 pounds will have nearly 30 pounds of skin.

4. YOUR SKIN RENEWS ITSELF EVERY 28 TO 30 DAYS.

New cells are created in that deep layer of the skin and take about four weeks to rise to the surface. There, they grow hard and then shed. This process, in which old skin is sloughed off and replaced by newer skin, might occur more than 1000 times over the average American's lifespan. But all skin is not created equal: Its thickness varies naturally among all areas of the body. Thickness can also be affected by age, gender, and habits (like smoking) that can change the cells' elasticity and other traits. According to Patel, the skin on the soles of your feet is up to seven times thicker than the skin of your eyelids.

5. TATTOOS STAY PUT, THANKS TO CELLS CALLED MACROPHAGES.

If your skin cells shed every month, how do tattoos stick around? It turns out to be a function of your immune system. The puncture of the tattoo needle causes inflammation in the dermis, the skin's middle layer. In response, white blood cells known as macrophages are sent in to help heal the damage. These macrophages "eat" the dye and can pass it to newer macrophages when they die off, so the pigment is essentially transferred from one cell to another. Any leftover pigment is soaked up by fibroblasts, which are longer-lasting skin cells that don't regenerate as often. Only lasers designed for tattoo removal are strong enough to kill off the macrophages and fibroblasts that hold the dye.

6. YOUR SKIN IS HOST TO BILLIONS OF CREATURES.

Your skin hosts a microbiome that can contain more than 1000 types of bacteria (along with other microbes, viruses, and pathogens). These "tiny ecosystems," as Patel describes them, are mostly friendly bacteria that work in concert with our bodies for many beneficial purposes, including wound healing, reducing skin inflammation, and assisting the immune system to help fight infection. These bacteria were once thought to outnumber your own cells 10 to one, but more recent research has found the ratio is closer to 1:1.

7. ANCIENT EGYPTIANS PUT SALT (AND OTHER FOODS) IN THEIR WOUNDS.

Injuring or breaking the skin's dermis, the layer below the epidermis, can expose the inner tissues to pathogens. To prevent infections from reaching any further into the skin, body fat, or muscle, ancient Egyptians cared for topical wounds with salt (yes, really!), fresh meat, moldy bread, and onions.

While these may seem like unsanitary things to put on a cut, modern research has found that there was actually merit in their methods. With its high iron content, meat was a good blood coagulant and recommended for the first day of a wound, according to a 2016 paper in the Journal of the German Society of Dermatology. Salt and onions are both astringent, which can stop blood flow. Moldy bread likely had antibacterial properties—a very early form of penicillin, you might say. Skin wounds would then be sealed with a combination of oils, fats, honey, and plant fibers.

8. YOUR BODY'S FLUID BALANCE DEPENDS ON SKIN.

Your skin is a significant shield against billions of tiny microbes and pathogens. But just as importantly, skin keeps fluids in. Another way to think of this, Patel says, is that your skin resembles a brick and mortar pattern. The bricks are the cells. The mortar is made up of lipids, fatty acids, and other sticky proteins that form the watertight layer. "If you have any ‘holes' in skin where moisture can escape, which are more susceptible to damage, that leads to dryness, cracking, and inflammation," Patel says.

People who have suffered burns often have fluid-balance problems, says Robert T. Brodell, M.D., professor of dermatology at University of Mississippi Medical Center in Jackson, Mississippi. "Fluids are seeping out, and they can't keep them balanced internally," he tells Mental Floss. This can be incredibly dangerous, because fluid loss can cause the heart to stop pumping blood to the rest of the body. Dehydration, hypertension, and other problems may also occur when skin is injured.

9. A SKIN CONDITION CAN PUT YOU AT GREATER RISK OF OTHER DISEASES.

Psoriasis is an autoimmune condition in which the skin cells in an affected area grow rapidly, leading to excess skin buildup, inflammation, and a red and scaly rash. While it can be uncomfortable to live with the condition on its own, studies [PDF] have shown that inflammation of the skin can lead to inflammation of other tissues and internal organs, and eventually certain diseases. For example, psoriasis has been linked to a greater risk for heart disease, as well as diabetes, Crohn's disease, metabolic syndrome, and other conditions thought to be correlated with inflammation.

Patel says that association makes treatment even more important: "If one organ is inflamed, you have to make sure another isn't."

10. YOUR LEGS MAY BE THE DRIEST PART OF YOUR BODY.

Unless you live in the tropics, you've probably noticed that the skin of your lower legs becomes drier in winter—and there's a biological reason for that. "You have fewer oil glands on your legs than any other area of your body," Brodell tells Mental Floss. Oil (or sebaceous) glands, found near the dermis's border with the epidermis, secrete an oily substance called sebum that lubricates skin and hair. As people age, the glands secrete less oil, and that means drier skin. Winter's low humidity and our tendency to spend more time around heat sources dries out skin even more.

The solution is to install a humidifier or apply some moisturizer. Certain skincare products, such as those with emulsifiers like sodium laureth sulfate, can also dry out or irritate your skin, so read your labels carefully.

11. OVERHEATING IS A RISK IF YOU LACK SWEAT GLANDS.

Both types of sweat glands are also located in the dermis. Eccrine glands, found all over the body, emit sweat directly through pores in the epidermis. Apocrine glands release sweat along hair follicles, so it's no surprise that these glands are concentrated in the hairiest parts of the body—head, armpit, and groin. Both types help regulate body temperature: In hot conditions, the glands release water and fatty liquids to cool the skin.

A lack of sweat glands puts people in danger of overheating. Those with a condition known as anhidrotic ectodermal dysplasia have few to no sweat glands, so they can't properly cool off when the body overheats. "They get heatstroke easily," Brodell says. A subset of people with this disorder suffer from immunodeficiency. They produce low levels of antibodies and infection-fighting immune T- and B-cells, so they are more prone to skin and lung infections.

12. YOUR GUT AND YOUR SKIN ARE SYMBIOTIC.

The gut and the skin never come into direct contact with one another, yet research shows that the gut has a profound impact on the skin.

"The skin becomes very unhealthy when the microbiome of the gut goes into a state of dysbiosis," meaning when something attacks the gut's good bacteria, says Gregory Maguire, Ph.D., a former professor of neuroscience at UC San Diego and the founder and chief scientific officer of BioRegenerative Sciences, a stem-cell technology company.

Dysbiosis can lead to inflammation, irritation, rashes, and pain. "There's good evidence that eczema [or] atopic dermatitis is partially due to dysbiosis of the gut and skin," he says.

In a 2017 paper published in the Archives of Dermatological Research, Maguire writes that normal gut bacteria can actually calm the body's response to stress. A reduction in the release of the stress hormone cortisol, which is thought to cause breakouts, also reduces the chance of skin irritation—all thanks to microbes in your intestine.

13. RESEARCHERS ARE USING "GOOD" BACTERIA TO TREAT ACNE.

When the skin's pores get clogged with sebum from the sebaceous glands and dead cells, a condition usually associated with hormonal changes, you've got acne. Clogged pores that stay closed are called whiteheads; if the pore opens and reveals the gunk inside, it's a blackhead. (The medical term for a blackhead, an "open comedo," stems from a Latin phrase alluding to "worms which devour the body." But don't worry, blackheads are not actual worms living in your face.)

While acne may seem like a rite of passage associated with puberty, researchers are experimenting with fighting "bad" bacteria (in this case, Propiobacterium acnes, which is linked to acne breakouts) with "good" bacteria, also known as probiotics. "One of the things [probiotics] do is ferment things on the skin like ammonia and nitrites, and metabolize it and turn it into other chemicals that are beneficial to the stem cells in your skin," Maguire explains. A 2015 study in the Journal of Women's Dermatology and other research has found that applying topical probiotics like Streptococcus salivarius and Streptococcus thermophiles inhibits P. acnes and may make skin more resilient against it in the long run.

BY JORDAN ROSENFELD